EdgeMarket › What Baker Bros. Advisors Lp reported owning

What Baker Bros. Advisors Lp reported owning

As filed on Form 13F for the quarter ending 2026-03-31, up to 45 days after that date. Long-only US-listed equity — shorts, bonds, cash and non-US listings are not on the form, so this is one leg of the book, not the book.

Reported value

17.4B

Positions

84

Quarter

2026-03-31

Shown below

50
largest by value
holdingvalue% of booksharesprice1y
INCY
INCYTE CORP
2.9B16.6%30.7M127.81+48.3%
ONC
BeOne Medicines Ltd.
2.6B15.0%8.8M374.47+21.1%
INSM
INSMED Inc
1.2B7.0%7.4M125.77-2.8%
MDGL
MADRIGAL PHARMACEUTICALS, INC.
1.1B6.4%2.1M516.74+31.9%
ACAD
ACADIA PHARMACEUTICALS INC
954.9M5.5%42.9M29.50+18.3%
RVMD
Revolution Medicines, Inc.
929.3M5.3%9.6M209.46+479.3%
CELC
Celcuity Inc.
903.5M5.2%7.9M93.53+91.8%
KOD
Kodiak Sciences Inc.
759.3M4.4%19.9M38.33+303.5%
KYMR
Kymera Therapeutics, Inc.
721.1M4.1%8.7M119.80+182.9%
SMMT
Summit Therapeutics Inc.
690.0M4.0%36.4M13.16-49.1%
PRAX
Praxis Precision Medicines, Inc.
564.9M3.2%1.8M375.94+730.8%
RYTM
RHYTHM PHARMACEUTICALS, INC.
487.4M2.8%5.6M110.00+11.4%
ALKS
Alkermes plc.
354.0M2.0%10.0M48.33+66.8%
GRAL
GRAIL, Inc.
208.2M1.2%4.0M79.54+147.2%
EWTX
Edgewise Therapeutics, Inc.
207.1M1.2%6.6M44.18+219.2%
IONS
IONIS PHARMACEUTICALS INC
153.8M0.9%2.0M59.74+39.5%
KNSA
Kiniksa Pharmaceuticals International, plc
136.1M0.8%2.8M79.03+138.0%
IMVT
Immunovant, Inc.
135.6M0.8%5.5M44.37+199.4%
ROIV
Roivant Sciences Ltd.
134.8M0.8%4.9M36.30+209.7%
IDYA
IDEAYA Biosciences, Inc.
131.5M0.8%3.9M39.67+63.1%
ARWR
ARROWHEAD PHARMACEUTICALS, INC.
124.9M0.7%2.0M87.11+331.2%
STOK
Stoke Therapeutics, Inc.
108.6M0.6%3.3M32.29+67.1%
IMTX
Immatics N.V.
107.4M0.6%10.9M8.93+59.5%
ABCL
AbCellera Biologics Inc.
105.7M0.6%30.3M11.32+171.5%
ABVX
Abivax S.A.
97.5M0.6%875.8K114.95+59.9%
CRNX
Crinetics Pharmaceuticals, Inc.
85.4M0.5%2.4M84.69+191.1%
REPL
Replimune Group, Inc.
84.5M0.5%11.0M14.77+181.3%
unmapped CUSIP 15102KAA874.9M0.4%30.8M
NRIX
Nurix Therapeutics, Inc.
72.2M0.4%4.7M26.72+180.4%
DNLI
Denali Therapeutics Inc.
71.6M0.4%3.7M24.92+71.7%
DNTH
Dianthus Therapeutics, Inc. /DE/
71.5M0.4%852.2K111.10+374.4%
GLUE
Monte Rosa Therapeutics, Inc.
71.5M0.4%4.3M14.30+222.8%
GPCR
Structure Therapeutics Inc.
69.0M0.4%1.4M49.09+164.4%
TRDA
Entrada Therapeutics, Inc.
64.0M0.4%5.1M7.57+42.6%
BCYC
BICYCLE THERAPEUTICS PLC
50.5M0.3%10.9M4.37-37.8%
SYRE
Spyre Therapeutics, Inc.
50.4M0.3%1.0M106.49+551.3%
RAPP
Rapport Therapeutics, Inc.
48.4M0.3%1.5M48.24+236.9%
ALMS
ALUMIS INC.
44.3M0.3%2.0M24.17+448.1%
MIRM
Mirum Pharmaceuticals, Inc.
41.2M0.2%446.0K96.31+44.4%
VRDN
Viridian Therapeutics, Inc.\DE
38.6M0.2%2.0M24.29+33.9%
ELVN
Enliven Therapeutics, Inc.
35.5M0.2%905.2K59.82+204.3%
PRLD
Prelude Therapeutics Inc
34.6M0.2%10.1M6.63+531.4%
DBVT
DBV Technologies S.A.
30.5M0.2%1.5M14.55+48.5%
DSGN
Design Therapeutics, Inc.
27.5M0.2%2.6M14.99+212.9%
unmapped CUSIP 15230910026.6M0.2%670.8K
CTMX
CytomX Therapeutics, Inc.
23.4M0.1%5.0M3.28+66.5%
JBIO
Jade Biosciences, Inc.
23.1M0.1%1.6M21.34+211.5%
IRON
Disc Medicine, Inc.
22.4M0.1%349.7K79.81+35.9%
IMCR
Immunocore Holdings plc
22.1M0.1%734.4K36.88+13.5%
XENE
Xenon Pharmaceuticals Inc.
21.5M0.1%370.2K60.77+61.5%

A position that grew quarter on quarter may simply reflect a higher price: if the stock rose 40% and the manager did nothing, the reported value rose 40%. Reading that as accumulation is reading the price back to yourself. More on that →

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