EdgeMarketInstruments › PRLD

PRLD — Prelude Therapeutics Inc

US Healthcare Pharma & biotech equity mkt cap 529.1M
6.63 +2.00% today
USD · as of 2026-08-21

Price · 2024-08-26 → 2026-08-21

499 daily closes shown
52w low 0.98 · high 6.63

Anonymous view is capped at two years of history. A free account extends it to five, and Pro opens the whole archive back to 2020-09-25.

Performance

1 day+2.00%
1 week+19.46%
1 month+68.70%
3 months+53.12%
6 months+138.49%
Year to date+142.86%
1 year+531.43%
3 years+85.71%
5 years-79.39%

Technicals

RSI 1485.9
vs 50-day avg+40.04%
vs 200-day avg+95.16%
Volatility 1y199.3%
Max drawdown 1y-70.10%
Avg volume 30d449.3K
Daily bars held1,483
History from2020-09-25

Measured signals that fired on PRLD

datesignal measured base rate
2026-08-20Breakout to a 52-week high
price
-1.00% over 21 days · t = -8.58 · n = 24,386
statistically distinguishable from its control group
2026-06-30Equal highs taken out
structure
-0.70% over 21 days · t = -8.28 · n = 68,636
statistically distinguishable from its control group
2026-05-29Short volume far above its own normal
short
-0.76% over 21 days · t = -2.79 · n = 5,897
statistically distinguishable from its control group
2026-04-23Cluster buy: three or more insiders
insider
+0.63% over 21 days · t = 1.84 · n = 3,050
not distinguishable from its control group

Excess return against a matched control group, on a point-in-time universe that includes delisted companies. Most families do not survive that. How the measurement works →

Insider transactions (Form 4)

dateinsiderwhatshares pricevalue
2026-04-27Shah Rajeev M.
10% owner
Other Acquisition/Disposition1.4M
2026-04-27Kolchinsky Peter
10% owner
Other Acquisition/Disposition1.4M
2026-04-27RA CAPITAL MANAGEMENT, L.P.
10% owner
Other Acquisition/Disposition1.4M
2026-04-27RA Capital Healthcare Fund LP
10% owner
Other Acquisition/Disposition1.4M
2026-04-21Bonita David P
Director
Open-market purchase1.7M4.447.5M
2026-04-21ORBIMED ADVISORS LLC
Director
Open-market purchase1.7M4.447.5M
2026-04-21OrbiMed Capital GP VI LLC
Director
Open-market purchase1.7M4.447.5M
2026-04-21ORBIMED CAPITAL LLC
Director
Open-market purchase1.7M4.447.5M
2026-04-21OrbiMed Genesis GP LLC
Director
Open-market purchase1.7M4.447.5M
2026-04-21ORBIMED CAPITAL LLC
Director
Open-market purchase1.1M4.445.0M

Open-market purchases (code P) are the informative ones. Grants, option exercises and tax withholding are compensation mechanics, not decisions. How to read a Form 4 →

Largest institutional holders

managervalueshares
ORBIMED ADVISORS LLC37.3M10.9M
BAKER BROS. ADVISORS LP34.6M10.1M
Kynam Capital Management, LP5.4M1.6M
VANGUARD CAPITAL MANAGEMENT LLC4.2M1.2M
EcoR1 Capital, LLC3.2M947.0K
TWO SIGMA INVESTMENTS, LP3.2M923.6K
SPHERA FUNDS MANAGEMENT LTD.1.9M558.3K
MILLENNIUM MANAGEMENT LLC1.3M382.7K
MARSHALL WACE, LLP1.2M358.9K
MORGAN STANLEY1.1M322.2K

13F positions as of 2026-03-31, filed up to 45 days after quarter end. Long-only US equity — shorts and derivatives never appear. What 13F does and does not show →

Latest SEC filings

formfiledperiod
10-Q2026-08-112026-06-30on EDGAR ↗
8-K2026-08-112026-08-11on EDGAR ↗
SCHEDULE 13G2026-07-08on EDGAR ↗
42026-06-102026-06-09on EDGAR ↗
42026-06-102026-06-09on EDGAR ↗
42026-06-102026-06-09on EDGAR ↗
42026-06-102026-06-09on EDGAR ↗
42026-06-102026-06-09on EDGAR ↗

Short selling

Avg short volume, 90d55.5% of tape
Days observed61

This is off-exchange short volume, not short interest: it is flow, not position, and 40–50% is normal because market makers short to fill your buy. Why that number misleads →

Recent headlines

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