EdgeMarketInstruments › PRAX

PRAX — Praxis Precision Medicines, Inc.

US Healthcare Pharma & biotech equity mkt cap 10.5B
375.94 +3.20% today
USD · as of 2026-08-21

Price · 2024-08-26 → 2026-08-21

499 daily closes shown
52w low 37.70 · high 386.33

Anonymous view is capped at two years of history. A free account extends it to five, and Pro opens the whole archive back to 2020-10-16.

Performance

1 day+3.20%
1 week+2.49%
1 month+16.61%
3 months+7.24%
6 months+12.13%
Year to date+31.26%
1 year+730.81%
3 years+2117.94%
5 years+81.61%

Technicals

RSI 1469.0
vs 50-day avg+16.06%
vs 200-day avg+25.82%
Volatility 1y199.4%
Max drawdown 1y-32.61%
Avg volume 30d392.2K
Daily bars held1,468
History from2020-10-16

Measured signals that fired on PRAX

datesignal measured base rate
2026-08-13Equal highs taken out
structure
-0.70% over 21 days · t = -8.28 · n = 68,636
statistically distinguishable from its control group
2026-08-06Breakout to a 52-week high
price
-1.00% over 21 days · t = -8.58 · n = 24,386
statistically distinguishable from its control group
2026-08-06Fair value gap, bullish
structure
-0.67% over 21 days · t = -6.43 · n = 111,973
statistically distinguishable from its control group
2026-07-29Fair value gap, bearish
structure
-0.45% over 21 days · t = -3.29 · n = 108,591
statistically distinguishable from its control group
2026-06-08Equal lows taken out
structure
-0.64% over 21 days · t = -4.75 · n = 55,661
statistically distinguishable from its control group
2026-06-02Bollinger bandwidth breaks out of its own compression
structure
-0.63% over 21 days · t = -2.80 · n = 7,196
statistically distinguishable from its control group

Excess return against a matched control group, on a point-in-time universe that includes delisted companies. Most families do not survive that. How the measurement works →

Insider transactions (Form 4)

dateinsiderwhatshares pricevalue
2026-07-08Souza Marcio
Chief Executive Officer
Gift20.5K0.000
2026-07-08Souza Marcio
Chief Executive Officer
Gift2.6K0.000
2026-06-24DeSimone Jill
Director
Open-market sale 10b5-1 plan2.9K311.91890.2K
2026-06-24DeSimone Jill
Director
Open-market sale 10b5-1 plan1.8K310.89544.1K
2026-06-24DeSimone Jill
Director
Option exercise 10b5-1 plan3.0K147.30446.9K
2026-06-24DeSimone Jill
Director
Open-market sale 10b5-1 plan1.3K314.90402.8K
2026-06-24DeSimone Jill
Director
Open-market sale 10b5-1 plan1.2K308.24382.2K
2026-06-24DeSimone Jill
Director
Option exercise 10b5-1 plan8.6K44.25379.0K
2026-06-24DeSimone Jill
Director
Open-market sale 10b5-1 plan1.0K312.83314.1K
2026-06-24DeSimone Jill
Director
Open-market sale 10b5-1 plan999309.38309.1K

Open-market purchases (code P) are the informative ones. Grants, option exercises and tax withholding are compensation mechanics, not decisions. How to read a Form 4 →

Largest institutional holders

managervalueshares
JANUS HENDERSON GROUP PLC1.1B3.5M
Orbis Allan Gray Ltd796.6M2.5M
BlackRock, Inc.749.1M2.3M
FMR LLC696.2M2.2M
PERCEPTIVE ADVISORS LLC656.0M2.0M
BAKER BROS. ADVISORS LP564.9M1.8M
VANGUARD CAPITAL MANAGEMENT LLC393.7M1.2M
DEERFIELD MANAGEMENT COMPANY, L.P.310.4M963.4K
Driehaus Capital Management LLC305.8M949.2K
Cormorant Asset Management, LP285.3M885.5K

13F positions as of 2026-03-31, filed up to 45 days after quarter end. Long-only US equity — shorts and derivatives never appear. What 13F does and does not show →

Short selling

Avg short volume, 90d63.7% of tape
Days observed61

This is off-exchange short volume, not short interest: it is flow, not position, and 40–50% is normal because market makers short to fill your buy. Why that number misleads →

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