EdgeMarketInstruments › IONS

IONS — IONIS PHARMACEUTICALS INC

US Healthcare Pharma & biotech equity mkt cap 9.8B
59.74 +1.67% today
USD · as of 2026-08-21

Price · 2024-08-26 → 2026-08-21

499 daily closes shown
52w low 41.82 · high 86.50

Anonymous view is capped at two years of history. A free account extends it to five, and Pro opens the whole archive back to 2016-01-04.

Performance

1 day+1.67%
1 week+4.37%
1 month+6.93%
3 months-21.17%
6 months-28.15%
Year to date-25.02%
1 year+39.55%
3 years+51.05%
5 years+50.55%

Technicals

RSI 1467.0
vs 50-day avg-6.68%
vs 200-day avg-19.26%
Volatility 1y53.0%
Max drawdown 1y-40.15%
Avg volume 30d3.0M
Daily bars held2,674
History from2016-01-04

Measured signals that fired on IONS

datesignal measured base rate
2026-07-16Equal lows taken out
structure
-0.64% over 21 days · t = -4.75 · n = 55,661
statistically distinguishable from its control group
2026-07-09Fair value gap, bearish
structure
-0.45% over 21 days · t = -3.29 · n = 108,591
statistically distinguishable from its control group
2026-07-06Fair value gap, bullish
structure
-0.67% over 21 days · t = -6.43 · n = 111,973
statistically distinguishable from its control group
2026-06-25Equal highs taken out
structure
-0.70% over 21 days · t = -8.28 · n = 68,636
statistically distinguishable from its control group
2026-06-02Fair value gap, bearish
structure
-0.45% over 21 days · t = -3.29 · n = 108,591
statistically distinguishable from its control group
2026-04-17Cluster sale: three or more insiders
insider
-0.36% over 21 days · t = -3.35 · n = 21,529
statistically distinguishable from its control group

Excess return against a matched control group, on a point-in-time universe that includes delisted companies. Most families do not survive that. How the measurement works →

Insider transactions (Form 4)

dateinsiderwhatshares pricevalue
2026-07-31Hayden Michael R
Director
Open-market purchase5.0K51.60258.0K
2026-07-30Hayden Michael R
Director
Open-market purchase15.0K53.38800.7K
2026-07-15BERTHELSEN SPENCER R
Director
Option exercise5.2K0.000
2026-07-15HERMAN JOAN E
Director
Option exercise5.2K0.000
2026-07-07BENNETT C FRANK
EVP, Chief Scientific Officer
Open-market sale 10b5-1 plan15.0K85.461.3M
2026-07-07Diaz Allene M.
Director
Open-market sale 10b5-1 plan10.1K85.42863.6K
2026-07-07Diaz Allene M.
Director
Option exercise 10b5-1 plan10.1K47.11476.3K
2026-07-07BENNETT C FRANK
EVP, Chief Scientific Officer
Open-market sale 10b5-1 plan5.5K83.58462.7K
2026-07-07Kordasiewicz Holly B.
EVP, Chief Development Officer
Open-market sale 10b5-1 plan36284.3030.5K
2026-07-07BENNETT C FRANK
EVP, Chief Scientific Officer
Other Acquisition/Disposition 10b5-1 plan15.0K0.000

Open-market purchases (code P) are the informative ones. Grants, option exercises and tax withholding are compensation mechanics, not decisions. How to read a Form 4 →

Largest institutional holders

managervalueshares
FMR LLC1.8B24.6M
Capital World Investors1.6B21.2M
BlackRock, Inc.784.1M10.4M
VANGUARD PORTFOLIO MANAGEMENT LLC586.4M7.8M
VANGUARD CAPITAL MANAGEMENT LLC534.5M7.1M
WELLINGTON MANAGEMENT GROUP LLP480.0M6.4M
TWO SIGMA INVESTMENTS, LP439.8M5.9M
GEODE CAPITAL MANAGEMENT, LLC305.2M4.0M
STATE STREET CORP300.0M4.0M
ROYAL BANK OF CANADA285.5M3.8M

13F positions as of 2026-03-31, filed up to 45 days after quarter end. Long-only US equity — shorts and derivatives never appear. What 13F does and does not show →

Latest SEC filings

formfiledperiod
42026-07-312026-07-30on EDGAR ↗
S-82026-07-31on EDGAR ↗
10-Q2026-07-292026-06-30on EDGAR ↗
8-K2026-07-292026-07-29on EDGAR ↗
42026-07-172026-07-15on EDGAR ↗
42026-07-172026-07-15on EDGAR ↗
42026-07-172026-07-15on EDGAR ↗
42026-07-172026-07-15on EDGAR ↗

Short selling

Avg short volume, 90d57.9% of tape
Days observed61

This is off-exchange short volume, not short interest: it is flow, not position, and 40–50% is normal because market makers short to fill your buy. Why that number misleads →

Ask the AI about IONS

The assistant reads every block on this page — price history, filings, insider transactions, institutional positions, short volume, macro and the measured base rates — and says what it implies, quoting the number behind each claim and declaring what it does not have.

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