UPB — Upstream Bio, Inc.
Price · 2024-10-11 → 2026-08-21
466 daily closes shownAnonymous view is capped at two years of history. A free account extends it to five, and Pro opens the whole archive back to 2024-10-11.
Performance
Technicals
Others in Healthcare
Measured signals that fired on UPB
| date | signal | measured base rate |
|---|---|---|
| 2026-06-17 | Cluster sale: three or more insiders insider | -0.37% over 21 days · t = -3.38 · n = 21,542 statistically distinguishable from its control group |
| 2026-03-19 | Fair value gap, bearish structure | -0.45% over 21 days · t = -3.29 · n = 108,591 statistically distinguishable from its control group |
| 2026-03-17 | Cluster sale: three or more insiders insider | -0.37% over 21 days · t = -3.38 · n = 21,542 statistically distinguishable from its control group |
| 2026-03-12 | Fair value gap, bullish structure | -0.67% over 21 days · t = -6.43 · n = 111,973 statistically distinguishable from its control group |
Excess return against a matched control group, on a point-in-time universe that includes delisted companies. Most families do not survive that. How the measurement works →
Insider transactions (Form 4)
| date | insider | what | shares | price | value |
|---|---|---|---|---|---|
| 2026-06-16 | Sutherland Everett Rand Chief Executive Officer | Open-market sale | 2.1K | 6.10 | 12.8K |
| 2026-06-16 | Deykin Aaron Chief Medical Officer | Open-market sale | 895 | 6.10 | 5.5K |
| 2026-06-16 | GRAY MICHAEL CFO and COO | Open-market sale | 853 | 6.10 | 5.2K |
| 2026-06-16 | Houghton Adam Chief Business Officer | Open-market sale | 700 | 6.10 | 4.3K |
| 2026-06-16 | Ambrose Allison General Counsel | Open-market sale | 477 | 6.10 | 2.9K |
| 2026-03-16 | Sutherland Everett Rand Chief Executive Officer | Open-market sale | 2.1K | 9.29 | 19.4K |
| 2026-03-16 | Deykin Aaron Chief Medical Officer | Open-market sale | 894 | 9.29 | 8.3K |
| 2026-03-16 | GRAY MICHAEL CFO and COO | Open-market sale | 852 | 9.29 | 7.9K |
| 2026-03-16 | Houghton Adam Chief Business Officer | Open-market sale | 699 | 9.29 | 6.5K |
| 2026-03-16 | Ambrose Allison General Counsel | Open-market sale | 475 | 9.29 | 4.4K |
Open-market purchases (code P) are the informative ones. Grants, option exercises and tax withholding are compensation mechanics, not decisions. How to read a Form 4 →
Largest institutional holders
| manager | value | shares |
|---|---|---|
| FMR LLC | 72.9M | 8.1M |
| ORBIMED ADVISORS LLC | 51.2M | 5.7M |
| BlackRock, Inc. | 30.3M | 3.4M |
| Decheng Capital LLC | 24.5M | 2.7M |
| ENAVATE SCIENCES GP, LLC | 22.1M | 2.5M |
| VANGUARD CAPITAL MANAGEMENT LLC | 16.9M | 1.9M |
| Y-Intercept (Hong Kong) Ltd | 9.0M | 1.0M |
| FEDERATED HERMES, INC. | 8.8M | 979.8K |
| GEODE CAPITAL MANAGEMENT, LLC | 8.6M | 950.6K |
| MILLENNIUM MANAGEMENT LLC | 8.4M | 937.3K |
13F positions as of 2026-03-31, filed up to 45 days after quarter end. Long-only US equity — shorts and derivatives never appear. What 13F does and does not show →
Latest SEC filings
| form | filed | period | |
|---|---|---|---|
| SCHEDULE 13G/A | 2026-08-12 | — | on EDGAR ↗ |
| 10-Q | 2026-08-11 | 2026-06-30 | on EDGAR ↗ |
| 8-K | 2026-08-11 | 2026-08-11 | on EDGAR ↗ |
| SCHEDULE 13G | 2026-07-30 | — | on EDGAR ↗ |
| 4 | 2026-06-17 | 2026-06-16 | on EDGAR ↗ |
| 4 | 2026-06-17 | 2026-06-16 | on EDGAR ↗ |
| 4 | 2026-06-17 | 2026-06-16 | on EDGAR ↗ |
| 4 | 2026-06-17 | 2026-06-16 | on EDGAR ↗ |
Short selling
This is off-exchange short volume, not short interest: it is flow, not position, and 40–50% is normal because market makers short to fill your buy. Why that number misleads →
Recent headlines
- Upstream Bio, Inc. (UPB) filed form 8-K · 2026-08-11 · SEC EDGAR
Ask the AI about UPB
The assistant reads every block on this page — price history, filings, insider transactions, institutional positions, short volume, macro and the measured base rates — and says what it implies, quoting the number behind each claim and declaring what it does not have.
Everything on this page is live in the terminal.
Charts, filings, insider flow and the AI — open without an account.
Free plan for good. Pro is $69.99/mo, or $4.99 for a 7-day trial. See the plans →