EdgeMarketInstruments › PRME

PRME — Prime Medicine, Inc.

US Healthcare Pharma & biotech equity mkt cap 614.9M
3.39 +4.63% today
USD · as of 2026-08-21

Price · 2024-08-26 → 2026-08-21

499 daily closes shown
52w low 2.70 · high 6.67

Anonymous view is capped at two years of history. A free account extends it to five, and Pro opens the whole archive back to 2016-01-05.

Performance

1 day+4.63%
1 week+9.71%
1 month+14.14%
3 months+14.92%
6 months+3.67%
Year to date-3.97%
1 year+4.63%
3 years-70.85%
5 years-83.19%

Technicals

RSI 1464.4
vs 50-day avg+3.28%
vs 200-day avg-4.67%
Volatility 1y89.5%
Max drawdown 1y-59.52%
Avg volume 30d2.8M
Daily bars held2,673
History from2016-01-05

Measured signals that fired on PRME

datesignal measured base rate
2026-08-21Bollinger bandwidth breaks out of its own compression
structure
-0.63% over 21 days · t = -2.80 · n = 7,196
statistically distinguishable from its control group
2026-07-13Fair value gap, bearish
structure
-0.45% over 21 days · t = -3.29 · n = 108,591
statistically distinguishable from its control group
2026-07-08Fair value gap, bullish
structure
-0.67% over 21 days · t = -6.43 · n = 111,973
statistically distinguishable from its control group
2026-07-02Equal highs taken out
structure
-0.70% over 21 days · t = -8.28 · n = 68,636
statistically distinguishable from its control group
2026-06-11Equal lows taken out
structure
-0.64% over 21 days · t = -4.75 · n = 55,661
statistically distinguishable from its control group
2026-03-30Fair value gap, bearish
structure
-0.45% over 21 days · t = -3.29 · n = 108,591
statistically distinguishable from its control group

Excess return against a matched control group, on a point-in-time universe that includes delisted companies. Most families do not survive that. How the measurement works →

Insider transactions (Form 4)

dateinsiderwhatshares pricevalue
2025-08-01ARCH Venture Fund X Overage, L.P.
Open-market purchase3.0M3.3010.0M
2025-08-01ARCH Venture Partners X Overage, L.P.
Open-market purchase3.0M3.3010.0M
2025-08-01ARCH Venture Fund X, L.P.
Open-market purchase3.0M3.3010.0M
2025-08-01ARCH Venture Fund XII, L.P.
Open-market purchase3.0M3.3010.0M
2025-08-01ARCH Venture Partners XII, LLC
Open-market purchase3.0M3.3010.0M
2025-08-01ARCH Venture Partners XII, L.P.
Open-market purchase3.0M3.3010.0M
2025-08-01CRANDELL KEITH
Open-market purchase3.0M3.3010.0M
2025-08-01GILLIS STEVEN
Open-market purchase3.0M3.3010.0M
2025-08-01Burow Kristina
Open-market purchase3.0M3.3010.0M
2025-08-01ARCH Venture Partners X, LLC
Open-market purchase3.0M3.3010.0M

Open-market purchases (code P) are the informative ones. Grants, option exercises and tax withholding are compensation mechanics, not decisions. How to read a Form 4 →

Largest institutional holders

managervalueshares
Alphabet Inc.57.6M16.6M
BlackRock, Inc.29.6M8.5M
STATE STREET CORP22.1M6.3M
ARK Investment Management LLC21.7M6.2M
VANGUARD CAPITAL MANAGEMENT LLC15.6M4.5M
Balyasny Asset Management L.P.14.3M4.1M
Casdin Capital, LLC11.0M3.2M
Woodline Partners LP10.5M3.0M
Sumitomo Mitsui Trust Group, Inc.10.2M2.9M
Amova Asset Management Americas, Inc.10.2M2.9M

13F positions as of 2026-03-31, filed up to 45 days after quarter end. Long-only US equity — shorts and derivatives never appear. What 13F does and does not show →

Short selling

Avg short volume, 90d52.1% of tape
Days observed61

This is off-exchange short volume, not short interest: it is flow, not position, and 40–50% is normal because market makers short to fill your buy. Why that number misleads →

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