EdgeMarket › What Rtw Investments, Lp reported owning

What Rtw Investments, Lp reported owning

As filed on Form 13F for the quarter ending 2026-03-31, up to 45 days after that date. Long-only US-listed equity — shorts, bonds, cash and non-US listings are not on the form, so this is one leg of the book, not the book.

Reported value

10.0B

Positions

88

Quarter

2026-03-31

Shown below

50
largest by value
holdingvalue% of booksharesprice1y
MDGL
MADRIGAL PHARMACEUTICALS, INC.
1.0B10.4%2.0M516.74+31.9%
INSM
INSMED Inc
791.9M7.9%4.8M125.77-2.8%
PTGX
Protagonist Therapeutics, Inc
533.2M5.3%5.1M154.32+174.4%
PTCT
PTC THERAPEUTICS, INC.
527.8M5.3%7.7M69.82+42.9%
ARGX
ARGENX SE
518.1M5.2%709.4K1,039.78+57.3%
CGON
CG Oncology, Inc.
472.7M4.7%7.0M79.81+212.6%
CELC
Celcuity Inc.
346.9M3.5%3.0M93.53+91.8%
TNGX
Tango Therapeutics, Inc.
278.2M2.8%13.3M23.88+253.8%
ERAS
Erasca, Inc.
261.4M2.6%16.2M17.63+1107.5%
NTRA
Natera, Inc.
250.0M2.5%1.2M332.03+106.7%
RDNT
RadNet, Inc.
239.5M2.4%4.3M76.82+11.9%
TARS
Tarsus Pharmaceuticals, Inc.
234.7M2.3%3.3M72.70+31.2%
APGE
Apogee Therapeutics, Inc.
234.2M2.3%2.8M134.75+274.1%
SYRE
Spyre Therapeutics, Inc.
210.4M2.1%4.2M106.49+551.3%
COGT
Cogent Biosciences, Inc.
210.1M2.1%5.5M36.73+209.6%
IRTC
iRhythm Holdings, Inc.
196.9M2.0%1.7M128.52-21.2%
STOK
Stoke Therapeutics, Inc.
183.1M1.8%5.6M32.29+67.1%
CYTK
CYTOKINETICS INC
179.4M1.8%2.7M76.84+105.9%
ACAD
ACADIA PHARMACEUTICALS INC
159.0M1.6%7.1M29.50+18.3%
ESTA
ESTABLISHMENT LABS HOLDINGS INC.
150.8M1.5%2.7M72.67+85.9%
unmapped CUSIP 03753U106148.2M1.5%3.7M
IMCR
Immunocore Holdings plc
146.8M1.5%4.9M36.88+13.5%
RGEN
REPLIGEN CORP
142.1M1.4%1.2M181.13+49.0%
NBIX
NEUROCRINE BIOSCIENCES INC
139.9M1.4%1.1M152.57+14.5%
GH
Guardant Health, Inc.
136.8M1.4%1.5M170.69+191.8%
IMTX
Immatics N.V.
126.6M1.3%12.9M8.93+59.5%
ZLAB
Zai Lab Ltd
123.7M1.2%6.6M26.01-22.4%
BLTE
BELITE BIO, INC
114.1M1.1%715.3K161.06+154.0%
ISRG
INTUITIVE SURGICAL INC
101.4M1.0%220.0K378.81-21.2%
ORKA
Oruka Therapeutics, Inc.
101.0M1.0%2.1M107.96+649.7%
GHRS
GH Research PLC
83.4M0.8%5.9M28.33+121.7%
XNCR
Xencor Inc
81.7M0.8%6.8M27.80+270.2%
URGN
UroGen Pharma Ltd.
81.7M0.8%4.5M46.86+142.7%
unmapped CUSIP 15230910081.6M0.8%2.1M
IMVT
Immunovant, Inc.
78.9M0.8%3.2M44.37+199.4%
RARE
Ultragenyx Pharmaceutical Inc.
76.4M0.8%3.6M25.83-12.0%
HNGE
Hinge Health, Inc.
74.4M0.7%1.9M88.42+54.5%
CSTL
CASTLE BIOSCIENCES INC
67.7M0.7%2.8M34.20+72.9%
RCKT
ROCKET PHARMACEUTICALS, INC.
63.3M0.6%17.7M3.51-6.4%
TSHA
Taysha Gene Therapies, Inc.
61.2M0.6%13.7M6.09+112.2%
ALKS
Alkermes plc.
59.1M0.6%1.7M48.33+66.8%
CMPS
COMPASS Pathways plc
58.8M0.6%10.6M13.33+226.7%
KOD
Kodiak Sciences Inc.
56.7M0.6%1.5M38.33+303.5%
REPL
Replimune Group, Inc.
56.3M0.6%7.4M14.77+181.3%
CRNX
Crinetics Pharmaceuticals, Inc.
52.7M0.5%1.5M84.69+191.1%
QURE
uniQure N.V.
42.3M0.4%2.6M48.37+212.5%
WAY
Waystar Holding Corp.
39.3M0.4%1.6M25.01-28.7%
ARWR
ARROWHEAD PHARMACEUTICALS, INC.
36.7M0.4%585.7K87.11+331.2%
OBIO
Orchestra BioMed Holdings, Inc.
35.3M0.4%8.3M5.36+120.6%
VSTM
Verastem, Inc.
34.9M0.3%6.6M6.89-17.2%

A position that grew quarter on quarter may simply reflect a higher price: if the stock rose 40% and the manager did nothing, the reported value rose 40%. Reading that as accumulation is reading the price back to yourself. More on that →

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